Clinical Data

Original U.S. Army Institute of Surgical Research Burn Center Retrospective Review of 70 patients1 J Salinas et al, 2011

Key Findings:

  • 35% additional time in target UO range
  • 24 hour fluids given reduced from 6.5 to 4.2 mL/kg/TBSA (Total Body Surface Area burned)
  • 2.5 fewer ventilator days
  • Mortality decreased from 44% to 29% between groups
U.S. Army burn center Retrospective Review of 207 patients2, J Salinas et al, 2012

Key Findings:

  • 24 hour fluids given were 3.5 mL/kg/TBSA
  • Mean urine output for initial 24 hours was 55 mL/hr
University of Texas Medical Branch Retrospective Review of 53 patients3, G Kramer et al, 2015 (poster presentation)

Key Findings:

  • Mean 24 hour fluids given reduced from 4.1 to 3.0 mL/kg/TBSA
  • Acceptance of recommendations was 89%
  • Unadjusted mortality 33% in before group, 17% in after group
University of Texas Medical Branch Retrospective Review of 154 patients4, J Sheaffer et al, 2017 (oral presentation)

Key Findings:

  • Acute Kidney Injury incidence reduced from 15% to 6% in first five days (p=.089)
Meta-Regression
35 Years of Burn Resuscitation
meta-regression graph
  1. J Salinas et al Review of Patients Resuscitated Using a Computerized Decision Support System in A Burn Intensive Care Unit. Crit Care Med 2012 225: Poster: Abstract only
  2. Kramer GC et al Computerized Decision Support for Burn Resuscitation. J Burn Care and Research 2015 36(3): S214

Meta-Regression graph adapted from Kramer poster² with permission.

References

  1. J Salinas et al, Computerized decision support system improves fluid resuscitation following severe burns: An original study. Crit Care Med 2011 39(9):2031-8.
  2. J Salinas et al, Review of Patients Resuscitated Using a Computerized Decision Support System in A Burn Intensive Care Unit. Crit Care Med 2012, 225: Abstract only.
  3. Kramer GC et al, Computerized Decision Support for Burn Resuscitation. J Burn Care and Research 2015, 36(3): S214
  4. Sheaffer J et al, Incidence of Acute Kidney Injury in Computerized Decision Support System Guided Fluid Resuscitations, American Burn Association Oral Presentation, 24 March 2017.